21 Nights Europe, Mediterranean

The capital of Catalonia boasts the bustle of the world's busiest seaport, the medieval romance of its Gothic Quarter, and a feast of Catalan Art Nouveau buildings - including the great creations of Antonio Gaudí. The "Great Enchantress" remains one of the most exhilarating cities in Europe, decorated with the grandeur of Picasso, Miró and Dalí.

The Strait of Messina is a narrow strait between the eastern tip of Sicily and the western tip of Calabria in the south of Italy. It connects the Tyrrhenian Sea to the north with the Ionian Sea to the south, within the central Mediterranean

This Sicilian port city is noted for the Duomo, an elegant reconstruction of the medieval cathedral built by Roger II, and the detached campanile, which contains the largest astronomical clock in the world. Ruins salvaged from past natural disasters are housed in the Museo Regionale.

Greece's capital and its largest city was born atop the Acropolis, where ancient warrior-kings once dwelled. These ruins are a testament to the golden age of Greece, and the Parthenon is considered the most architecturally sophisticated temples of its time. Ancient Agora, a sprawling array of stones, slabs and foundations, was once the focal point of ancient Greek life.

The Mississippi River is the second-longest river and chief river of the second-largest drainage system on the North American continent, second only to the Hudson Bay drainage system.

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents - Europe and Asia. Its old palaces, great mosques with soaring minarets, ancient churches, museums, bazaars, and the Istanbul Strait are all worth seeing. The Grand Bazaar, the Hagia Sophia, the Blue Mosque and the Topkapi Palace are impressive, unforgettable sites.

Once called Constantinople, the former capital of the Byzantine Empire is the only city in the world to straddle two continents - Europe and Asia. Its old palaces, great mosques with soaring minarets, ancient churches, museums, bazaars, and the Istanbul Strait are all worth seeing. The Grand Bazaar, the Hagia Sophia, the Blue Mosque and the Topkapi Palace are impressive, unforgettable sites.

The Mississippi River is the second-longest river and chief river of the second-largest drainage system on the North American continent, second only to the Hudson Bay drainage system.

This charming, Turkish resort is reputed as one of the most attractive cities on the Aegean Sea. It is known for the ancient ruins of Ephesus - one of the world's most wondrous archaeological sites. Other historical masterpieces include the Great Amphitheatre, where St. Paul addressed the Ephesians, the Selcuk castle, and the tombs of the Seven Sleepers.

Rhodes, Greece offers over 300 days of sunshine a year with an east coast abound with pristine sandy beaches. The old town of Rhodes is considered the largest inhabited medieval town in Europe, and its mighty fortifications are a splendid example of the defensive architecture of its time. The Acropolis of Lindos, in eastern Rhodes, is a must-see archaeological site.

Katakolon is a charming fishing village on the Ionian Coast that is the gateway to Olympia, the site of the first Olympic games in 776 B.C. Prominent ruins of the Sanctuary include the athletic quadrangles and the Temple of Zeus. The Archaeological Museum contains Archaic, Classical and Roman sculptures, including the famous Niki "Winged Victory."

The Strait of Messina is a narrow strait between the eastern tip of Sicily and the western tip of Calabria in the south of Italy. It connects the Tyrrhenian Sea to the north with the Ionian Sea to the south, within the central Mediterranean

The "Eternal City", with its 2,700 years of ancient history, is simply incomparable. Its formidable legacy is rooted in a plethora of masterpieces, including The Sistine Chapel, the Colosseum, the Trevi Fountain, The Roman Forum, the Pantheon, the Spanish Steps, St. Peter's Basilica and Piazza Novana.

War-torn Palermo was neglected for centuries after WWII, which ironically led to the preservation of the city's historic buildings and bombsites. Though it was once regarded as Europe's most beautiful city, the fanciful decay of Palermo is now what draws visitors.

The Strait of Messina is a narrow strait between the eastern tip of Sicily and the western tip of Calabria in the south of Italy. It connects the Tyrrhenian Sea to the north with the Ionian Sea to the south, within the central Mediterranean

Corfu was once ruled by Venetian doges, Turkish sultans and French invaders. Marvel at the 17th-century icons in St. George's Church, the medieval Palace of Phrourio and the 19th-century Achilleion Palace. The greenest of the Greek Isles, Corfu also boasts thriving vineyards and olive orchards among its rugged mountains.

Korcula make it the second most populous Adriatic island after Krk and the most populous Croatian island not connected to the mainland by a bridge

Zadar is one of the Dalmatian Coast's best-kept secrets? and adventure in this tucked-away treasure teems with centuries of charm. As the oldest continuously inhabited Croatian city, its timeworn history is perpetually on display among old city walls and Venetian gates. And its zany way of life keeps this dynamic city thriving today, from the waterfront Riva promenade to the untouched surrounding islands. One minute you might mingle over coffee in People's Square, the next plunge into turquoise waters off Ugljan Island. You can enter church treasuries, bicycle around Old Town, or check out fascinating museum exhibits. Adventure in Zadar leads you away from the crowds to discover off-the-beaten-path wonders.

Trieste is the capital city of the Friuli Venezia Giulia region in northeast Italy. A port city, it occupies a thin strip of land between the Adriatic coast and Slovenia's border on the limestone-dominated Karst Plateau. Italian, Austro-Hungarian and Slovenian influences are all evident in its layout, which encompasses a medieval old city and a neoclassical Austrian quarter